N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Names and Identifiers

Name	H-89 dihydrochloride
Synonyms	H89 IQB H-89 H-89 HYDROCHLORIDE H-89 dihydrochloride H-89 DIHYDROCHLORIDE H-89 DIHYDROCHLORIDE HYDRATE H-89 hydrate dihydrochloride N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE 5-Isoquinolinesulfonamide, N-(2-((3-(4-bromophenyl)-2-propenyl)amino)ethyl)- N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE dihydrochloride N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide N-(2-((3-(4-Bromophenyl)-2-propenyl)amino)ehtyl)-5-isoquinolinesulfonamide dihydrochloride N-(2-{[(2E)-3-(4-bromophenyl)prop-2-en-1-yl]amino}ethyl)isoquinoline-5-sulfonamide dihydrochloride
CAS	127243-85-0
InChI	InChI=1/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Physico-chemical Properties

Molecular Formula	C20H20BrN3O2S
Molar Mass	446.36
Density	1.436
Melting Point	195-200°C
Boling Point	639.7±65.0 °C(Predicted)
Flash Point	361.8°C
Solubility	H2O: ≥10mg/mL
Vapor Presure	1.95E-18mmHg at 25°C
Appearance	White-like powder
Color	off-white
pKa	10.43±0.50(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
MDL	MFCD00214120
Physical and Chemical Properties	Solubility: H2O: ≥ 10 mg/mL storage condition: 2-8 ℃ WGK Germany:3
In vitro study	H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca 2+ uptake by the SR and affectes the Ca 32 -sensitivity of the contractile apparatus in rat skinned fibres.
In vivo study	H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29350090

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Reference Information

biological activity	H-89 is an effective and selective cAMP-dependent protein kinase A inhibitor with an IC50 value of 48 nM, and its inhibitory effect on PKG,PKC,Casein Kinase and other kinases is very weak.
target	IC50: 48 nM (protein kinase A)

Last Update：2024-04-09 20:52:54

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: H-89 Visit Supplier Webpage Request for quotation
CAS: 127243-85-0
Tel: 18301782025
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Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: H-89 Visit Supplier Webpage Request for quotation
CAS: 127243-85-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE

H-89 dihydrochloride

CAS: 127243-85-0

Molecular Formula: C20H20BrN3O2S

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Names and Identifiers

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Physico-chemical Properties

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Risk and Safety

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Reference Information

Supplier List

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE Request for Quotation

H-89 dihydrochloride

CAS: 127243-85-0

Molecular Formula: C20H20BrN3O2S

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Names and Identifiers

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Physico-chemical Properties

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Risk and Safety

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE - Reference Information

Supplier List

N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE